After extraction and prior to cannabinoid isolation, (whether chromatography, crystallization or some other means), distillation should definitely be performed. Consider that your crude extract typically might be anywhere from 55% to 75% total cannabinoid in the feed, plus lighter components of terpenes, solvents and water (2-7%), with the remainder being heavier components such as lipids, sterols, chlorophyll, fatty acids, salts, sugars, and heavy waxes, (18-43%). Also consider that distillation, (which does not introduce any additional chemicals), will result in a clear yellow product distillate stream of between 80 to 95% purity cannabinoid and that a dark waste residue steam of 18-43% of unwanted feed material gets removed in the process! All this unwanted non-cannabinoid has no business being brought into the isolation operation, especially when it can be so easily removed beforehand. Leaving this heavy portion in taxes the isolation process resulting in less product purity and significantly lower yield of available product. In the case of chromatography, this waste product also fouls the chromatography media faster, resulting in shortened life of this expensive material. Also, the viewpoint that distillation is best omitted because it removes the “full spectrum, entourage” components is moot because when the product undergoes an isolation process, such components are definitely removed by definition of “isolation”. Terpenes and other components that one may want to include in the product can be added later, depending on the type of product that is being made.